Developmental regulation of X-chromosome inactivation
نویسندگان
چکیده
منابع مشابه
X Chromosome Inactivation in Opioid Addicted Women
Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...
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AS consistently demonstrated by confirmations of the Lyon hypothesis (LYON 1961, 1972), only one of the two X chromosomes is expressed genetically in females of eutherian mammals. Which of the two X chromosomes is to remain active is determined, apparently at random, during early embryogeny, and thereafter maintained in subsequent somatic cell lineages. In the germ line, however, both X's appea...
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In mammals, X-chromosome inactivation is imprinted in the extra-embryonic lineages with paternal X chromosome being preferentially inactivated. In this study, we investigate the role of Tsix, the antisense transcript from the Xist locus, in regulation of Xist expression and X-inactivation. We show that Tsix is transcribed from two putative promoters and its transcripts are processed. Expression...
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X-Chromosome Inactivation (XCI) is the process whereby one, randomly chosen X becomes transcriptionally silenced in female cells. XCI is governed by the Xic, a locus on the X encompassing an array of genes which interact with each other and with key molecular factors. The mechanism, though, establishing the fate of the X's, and the corresponding alternative modifications of the Xic architecture...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2016
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2016.04.014